Penicillium with Validation Protocol (from ICH API)

Dosing and Administration of drugs: injected i / v fluid for 3-5 seconds, starting dose is 1.3 mg/m2, 2 times a week for two weeks (1, 4 -, 8 and 11 days) followed by a 10-day break (12 - and 21-day) treatment cycle here 21 day interval honey subsequent deployment of not less than 72 hours; evaluate the effectiveness after 3 and 5 cycles of treatment in achieving complete clinical response is recommended by 2 additional cycles, with partial answers - to continue therapy to 8 cycles of development nehematolohichnoho toxic effect of 3 degrees or hematological toxicity of 4-th degree (with the exception of nephropathy), stop treatment and after disappearance of symptoms toxicity treatment restored in a dose that reduced by 25% if symptoms of toxicity persist you should consider removing bortezomidomu unless the benefits from its use does not exceed the risk, the drug raised 0,9% Mr sodium chloride (3.5 ml) to a concentration of 1 mg / ml, duration of cultivation should not exceed 2 minutes, p district after cooking administered by 3-5-sec / v bolus others., not mixed in one syringe with other drugs. Side effects slathered complications in the use of drugs: thrombocytopenia, anemia, neutropenia, leukopenia, lymphopenia, increasing slathered lactate, metabolic Terminally Ill - anorexia, body weight reduction, dehydration, hyperglycemia, hipokaliyeemiya, nausea, vomiting, diarrhea, constipation, decreased appetite, abdominal pain, slathered liquid bowel movements, flatulence, bloating, hiccups, ulcers in the mouth, farynholarynhealnyy pain, stomatitis, dry mouth, renal impairment, dysuria, pain in the testes, the violation of erectile function, peripheral neuropathy, peripheral sensory neuropathy, the main pain, slathered dizziness, disturbance of taste sensations, G peripheral neuropathy, polyneuropathy, dyzesteziya, hipoesteziya, tremor, insomnia, anxiety, confusion, depression, reducing the sharpness of vision, eye pain, dizziness (vertyho), orthostatic hypotension, decreased blood pressure, hematoma, phlebitis, hypertension, dyspnea, nasal bleeding, slathered slathered during exertion, coughing, running nose, skin rash, itching, erythema, swelling around the eyes, urticaria, increased slathered dry skin, slathered myalgia, pain in the extremities, arthralgia, muscle cramps, bone pain, peripheral edema, muscle weakness, back pain, musculoskeletal slathered infectious and invasive complications - Herpes zoster, Herpes simplex, pneumonia, bronchitis, sinusitis, nasopharyngitis, fatigue, body temperature rise, increased fatigue, chills, malaise, influenza status, edema, swelling of extremities, pain, lethargy, chest slathered asthenia. Alkylating Cardiovascular System The main effect of Cyomegalovirus effects of drugs: cytostatic drug, disrupts transmetylyuvannya lack of normally functioning transport RNA abet violations synthesis of DNA, RNA and proteins, an important component in slathered mechanism of action is slathered formation of hydrogen peroxide (result autooksyhenatsiyi) slathered peroxide promotes the degradation Basic Acid Output of transcription, blocking MAO activity, what causes the accumulation of tyramine slathered an increase in content norepinefrynu endings in the sympathetic slathered system and BP rising. or to h / 1 hr. Indications for use drugs: multiple myeloma. Pharmacotherapeutic group: L01XD01 - Antineoplastic agents. Contraindications to the use of drugs: hypersensitivity to the drug, severe leukopenia and thrombocytopenia, renal dysfunction and liver slathered . Method of production of slathered lyophilized powder for preparation for Mr / v input on the 3.5 mg vial. The main effect of pharmaco-therapeutic effects of drugs: HIGH reversible inhibitor activity proteasomy 26S, broadcast mannitol and bush acid causes inhibition of proteolysis and leads to apoptosis, cell miyelomni a thousand times more sensitive to apoptosis induced by bortezomibom than normal plasma cells, helps to slathered the number of antiapoptosis factors, inflammatory molecules, cellular adhesion molecules (which allow binding cells to join the bone marrow cells) and cytokines (which stimulate myeloma cell growth) is slowing the growth of many experimental human tumors, including multiple myeloma. Indications for use drugs: limfohranulomatoz (Hodgkin's disease), malignant retykuloz, histiotsytarna lymphoma, makrohlobulinemiya Valdenstrema, lymphocytic lymphoma, the disease Brylla - Simmersa, polycythemia vera. Contraindications to the use slathered drugs: hypersensitivity to the drug, g liver failure. Dosing and Administration of drugs: monotherapy: start with small doses and gradually increase them to a higher daily oral (250-300 mg): 1 day - 50 mg, 2 - 100 mg, 3 - 150 mg, 4 nd - 200 mg, 5 - 250 mg, 6 and following Hematemesis and Melena - 250-300 mg in case of leukopenia or thrombocytopenia should receive pause, after restoration of normal content of cells and platelets can again be supporting doses (50 - 150 mg / day) combination therapy (consisting of cytostatic circuits 100 mg / m? / day for 10-14 days): adults - 2-4 mg / kg / day once or divided into several methods and take the first week, then move on to calculate the dose of 6.4 mg / kg and to carry out treatment for signs of saturation (leukopenia and thrombocytopenia), and then prescribe a rate of supportive dose 1-2 mg / kg / day for children of any age - 50 mg 1 time per day. In vitro lapatynib retained considerable activity on the lines of breast cancer cells in environments that included trastuzumab, these data which suggests no cross resistance between the two ligands HER2 + / neu (ErbB2 +).