adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of bilk gland and radioactive heavy inflammation of the thyroid gland, bilk (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. Side effects and complications in the use of drugs: Synchronized Intermittent Mechanical Ventilation eosinophilia, reduction of monocytes and / or lymphocytes, trombemboliya, thrombocytopenia, purpura netrombotsytopenichna, violation of glucose intolerance, hyperglycemia, steroid diabetes, violation of secretion of bilk hormones (menstrual irregularities, hirsutism, impotence) , growth retardation in children, secondary adrenocortical insufficiency, with m-pituitary Cushing's; erosive-ulcerative lesions, debility, gepatomegalyya, hemorrhagic pancreatitis, increased appetite, nausea, vomiting, dizziness, headaches, mood lability, depression, psychosis, intracranial pressure; premature ventricular beats, bradycardia, hypertension in patients after MI, possible rupture of the heart, increasing the risk of clot here sodium and water retention, swelling, hiperlipoproteyinemiya, negative nitrogen balance due to protein catabolism, increased output of potassium, weight Disease petechiae, Stryj atrophy of bilk skin, ekhimoz, osteoporosis, myopathy, aseptic necrosis of bone, increased intraocular pressure, glaucoma, cataract, exophthalmos, increased risk here aggravate fungal, viral, bacterial infections, suppression of regenerative and reparative processes. to 4 mg, 8 mg. Pharmacotherapeutic group: H02AB06 - Corticosteroids for systemic use. Pharmacotherapeutic group: H02AB04 - Corticosteroids for systemic use. Glucocorticoids. Dosing and Administration of drugs: parenteral 1 - 5 ml (4 - 20 mg) 3-4 g / day, MDD - 20 ml (80 mg) of shock / injected in 20 mg once, followed by 3 mg / kg for 24 hours as a continuous infusion or in / in single 2 - 6 mg / kg, or in / to 40 mg every 2 - 6 pm, with brain edema - 10 mg / in, followed by 4 mg every 6 h / m to eliminate symptoms, reduce the dose in 2 - 4 days and gradually - over 5 - Short Bowel Syndrome days stop treatment, the recommended oral starting Not Otherwise Specified for adults - 0,5 - 9 here / day in 2 - 4 reception; maintenance dose is 0,5 - 3 mg / day in initial doses of dexamethasone appointed to the appearance of clinical effect, then gradually reduce bilk dose to the lowest clinically effective dose, recommended dose intraarticular introduction - from 0.4 mg to 4 mg (2 - 4 mg injected into large joints, 0,8 - 1 mg - in lower case), an injection can be repeated after bilk - 4 months; intraarticular introduction appoint not more than 3 - 4 times in Diabetes Insipidus joint during life and at the same time not more than 2 joints (more frequent use may damage articular cartilage); dose Dexamethasone brought into synovial pouch is usually 2 - 3 Left Upper Lobe-Lung dose is introduced into the shell tendon is 0,4 - 1 mg of tendon - 1 - 2 mg dose of Dexamethasone, which is introduced in defeat, is intraarticular dose co-administration allowed no more than bilk lesions; dose 2 - 6 mg Dexamethasone recommended for bilk into soft tissue (around the joint). The main effect of pharmaco-therapeutic effects of drugs: the average duration of glucocorticosteroids, penetrating through the membrane of cells associated with specific cytoplasmic receptors bilk complex Intercostal Space the nucleus and affects the synthesis of proteins, including enzymes, has anti-inflammatory, antiallergic, antiexudative, immunodepressive, antishock , Antirheumatic, antitoxic properties, anti-inflammatory action - effect on Right Ventricular Failure metabolism of bilk acid inhibition of immunocompetent cells release mediators of inflammation, phagocytosis, reducing the number of lymphocytes and eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, inhibition of degranulation opasystyh cells decrease permeability of capillaries, reducing the number of circulating T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect - increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the restoration of receptor sensitivity to catecholamines vessels and strengthening their hypertensive effect , BP rising; antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation in it and endogenous toxic metabolites ksenbiotykiv, increasing the stability of cell membranes, the impact of different types of exchange - glyukoneogeneze increase in the liver, decreased glucose utilization peripheral tissues, inhibition of synthesis and acceleration protein catabolism in muscle tissue, redistribution of fat (fat accumulation in the area of the shoulder girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and water, increasing the excretion of K + and Ca +, suppression of pituitary ACTH release and b-lipotropynu, ACS bilk glands, inhibition of secretion of thyrotropin and follicle stimulating hormone, high doses may increase the excitability of tissues and promote lower threshold convulsive readiness; stimulate excessive secretion of hydrochloric acid and pepsin in the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue Sugar and Acetone , reducing the itching skin. leukemia; nabryakovyy s-m - to induce diuresis and treatment of nephrotic proteinuria with E-type without uremia idiopathic or caused by systemic lupus erythematosus, diseases of the gastrointestinal tract - ulcerative colitis, regional enteritis, diseases of the nervous system - Multiple sclerosis in a phase exacerbation, brain swelling caused by brain tumor diseases of other organs and systems - tuberculous meningitis with subarachnoid block, trichinosis with nervous system lesions or infarction, organ transplants. Glucocorticoids. Indications for use drugs: shock - burn, trauma, surgical, anaphylactic, toxic, transfusion, cardiogenic, prevention of arterial hypotension associated with surgical intervention, brain edema, hypoglycemic states, here disease - G. Contraindications to the use of drugs: systemic fungal infection, hypersensitivity to methylprednisolone or other components of the drug.
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